Autocrine Role for Interleukin-8 in Bartonella henselae-Induced Angiogenesis
AM McCord, SI Resto-Ruiz, BE Anderson - Infection and Immunity, 2006 - Am Soc Microbiol
The gram-negative bacterium Bartonella henselae is capable of causing angiogenic lesions
as a result of infection. Previously, it has been shown that B. henselae infection can result in
production of the chemokine interleukin-8 (IL-8). In this study, we demonstrated that
monocytes, endothelial cells, and hepatocytes produce IL-8 in response to B. henselae
infection. We also investigated the role of IL-8 in B. henselae-induced endothelial cell
proliferation and capillary tube formation. Both in vitro angiogenesis assays were IL-8 …
as a result of infection. Previously, it has been shown that B. henselae infection can result in
production of the chemokine interleukin-8 (IL-8). In this study, we demonstrated that
monocytes, endothelial cells, and hepatocytes produce IL-8 in response to B. henselae
infection. We also investigated the role of IL-8 in B. henselae-induced endothelial cell
proliferation and capillary tube formation. Both in vitro angiogenesis assays were IL-8 …
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